With Rx: Prescription , Rubbernekkerz deliver an hour-long introspective range of alt-rock songs that create an emotional mood from a layering of sounds. Natural and synthetic textures blend to create a spacey backdrop for lyrics that circle around reflective and often melancholy themes. The styles borrowed from range from dark-wave to prog-rock. The topics dealt with in the lyrics include collisions of opposites (such as Machine vs. Animal , and Babylon ), and laws that compel speech. Quite intentionally, the tune that addresses that latter topic has no words, is likely the strongest statement on the album ( Compelled Speech ). A quirky dark sense of humor is seen throughout, such as in the song Van Goth , which appeals to the listener to show compassion for a strange goth character who seems to parallel Vincent van Gogh.

Chief Rubbernekker, Canadian (Toronto-area) Mark Harrington is joined on the song Wait a Minute by vocalist Simon Caine, who enjoyed fame in the early 1970s. Speaking of the past, one of these songs ( Pictures of Red ) was written by Mark in 1987!